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J.C. Helton J.D. Johnson W.L. Oberkampf C.J. Sallaberry 《Reliability Engineering & System Safety》2006,91(10-11):1414-1434
Three applications of sampling-based sensitivity analysis in conjunction with evidence theory representations for epistemic uncertainty in model inputs are described: (i) an initial exploratory analysis to assess model behavior and provide insights for additional analysis; (ii) a stepwise analysis showing the incremental effects of uncertain variables on complementary cumulative belief functions and complementary cumulative plausibility functions; and (iii) a summary analysis showing a spectrum of variance-based sensitivity analysis results that derive from probability spaces that are consistent with the evidence space under consideration. 相似文献
23.
Joos F. Miguel Snaddon Robert W. L. Johnson Neil A. 《Industry Applications, IEEE Transactions on》1985,(6):1366-1372
Droplet growth is examined in a water-in-oil type emulsion where the droplets are subjected exclusively to viscous and dielectrophoretic forces. The latter are produced by the interaction of the droplets with an otherwise uniformly imposed electric field. Theoretical considerations are presented as a basis for understanding and interpreting the experiments. An emulsion consisting of deionized water droplets in a silicone oil of specific gravity I is subjected to a uniform 60 Hz, ac electrostatic field. Initially, the droplets are fairly monodisperse with mean diameters of approximately 25 , sm. The changes in droplet size distributions with time are examined with a laser diffraction system for water volume fractions ranging from 0.001 to 0.1 and applied fields ranging from 52 to 520 kVm-1. The average droplet size increases exponentially with time; we examine the exponent's dependence on average field strength and droplet volume fraction. 相似文献
24.
Present-day computer-aided design (CAD) packages play only a small part in the area of mechanical engineering design, which involves the synthesis and embodiment of physical components to perform a pre-determined function without unwanted side effects. The computer cannot properly help the designer in this task until it is able to capture and process the function requirements of the design. This paper describes the computer system being developed for this purpose at the Engineering Design Centre at Cambridge University Engineering Department. The paper also explores some of the geometrical and programming implications raised. 相似文献
25.
Genetic algorithms in engineering electromagnetics 总被引:10,自引:0,他引:10
This paper presents a tutorial and overview of genetic algorithms for electromagnetic optimization. Genetic-algorithm (GA) optimizers are robust, stochastic search methods modeled on the concepts of natural selection and evolution. The relationship between traditional optimization techniques and the GA is discussed. Step-by-step implementation aspects of the GA are detailed, through an example with the objective of providing useful guidelines for the potential user. Extensive use is made of sidebars and graphical presentation to facilitate understanding. The tutorial is followed by a discussion of several electromagnetic applications in which the GA has proven useful. The applications discussed include the design of lightweight, broadband microwave absorbers, the reduction of array sidelobes in thinned arrays, the design of shaped-beam antenna arrays, the extraction of natural resonance modes of radar targets from backscattered response data, and the design of broadband patch antennas. Genetic-algorithm optimization is shown to be suitable for optimizing a broad class of problems of interest to the electromagnetic community. A comprehensive list of key references, organized by application category, is also provided 相似文献
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Applications of large-scale computer modeling and simulation to a class of bioelectric field problems in a variety of biomedical research areas, from single cells to full human structures, are described. The authors focus on a specific subset of bioelectric field problems that have applications in electrocardiography and electroencephalography. The physics and physiology of bioelectric volume conductors are introduced. A specific computational example and the authors' view on the future direction of computational medicine are presented 相似文献
28.
The Fusion program, a method for agile, flexible computer integrated manufacturing (CIM) at Motorola's Paging Products Group, is discussed. Fusion's CIM and automated assembly system can manufacture a wide variety of different products on the same production line. The development of the Fusion program and how it differs from its predecessor, the Bandit program, are described 相似文献
29.
We demonstrate multi-emitter Si/GexSi1-x n-p-n heterojunction bipolar transistors (HBT's) which require no base contact for transistor operation. The base current is supplied by the additional emitter contact under reverse bias due to the heavy doping of the emitter-base junction. Large-area HBT test structures exhibit good transistor characteristics, with current gain β≈400 regardless of whether the base current is supplied by a test base electrode or one of the emitter contacts. These devices have enhanced logic functionality because of emitter contact symmetry. Since device fabrication does not require base electrode formation, the number of processing steps can be reduced without significant penalty to HBT performance 相似文献
30.
D Cullinan F Johnson AP Grollman M Eisenberg C de los Santos 《Canadian Metallurgical Quarterly》1997,36(39):11933-11943
Vinyl chloride reacts with cellular DNA producing 3,N4-etheno-2'-deoxycytidine (epsilonC) along with other exocyclic adducts. The solution structure of an oligodeoxynucleotide duplex containing an epsilonC.dG base pair was determined by high-resolution NMR spectroscopy and molecular dynamics simulations. NMR data indicated that the duplex adopts a right-handed helical structure having all residues in anti orientation around the glycosylic torsion angle. The epsilonC adduct has a sugar pucker in the C3'-endo/C4'-exo region while the rest of the residues are in the C2'-endo/C3'-exo range. NOE interactions established Watson-Crick alignments for canonical base pairs of the duplex. The imino proton of the lesion-containing base pair resonated as a sharp signal that was resistant to water exchange, suggesting hydrogen bonding. Restrained molecular dynamics simulations generated three-dimensional models in excellent agreement with the spectroscopic data. The refined structures are slightly bent at the lesion site without major perturbations of the sugar-phosphate backbone. The adduct is displaced and shifted toward the major groove of the helix while its partner on the complementary strand remains stacked. The epsilonC(anti).dG(anti) base pair alignment is sheared and stabilized by the formation of hydrogen bonds. The biological implications of structures of epsilonC-containing DNA duplexes are discussed. 相似文献